HALO® Elevate 

For symmetrical peaks, even with basic analytes

The HALO^® Elevate is available in three phases: C18, C8, and phenyl-hexyl.

The organosilane-modified surface enables an operating range of pH 2–12 and reliably protects the silica material from degradation at high pH and elevated temperatures.
By operating at high pH, basic compounds can be analyzed in an uncharged state. This eliminates silanol interactions and delivers significantly improved peak symmetry, even with challenging analytes such as antidepressants, opioids, or cocaine metabolites.

The HALO^® Elevate is based on Fused-Core^® technology for fast, efficient separation.

• Organosilane-modified Fused-Core^® particles for alkali resistance at pH 2–12
• Excellent long-term stability and lot-to-lot reproducibility
• Improved peak shape and increased loading capacity for basic analytes
• LC/MS-compatible

Brochure

HALO^® Elevate Family

HALO^® Elevate C18

Advantages

High Temperature/ pH Amitriptyline Stability using HALO^® Elevate

Impact of pH on Retention for HALO^® Elevate

Applications

Elevating pH to Improve a Drugs of Abuse Separation

Nicotine Analysis Using HALO^® Elevate C18

Separation of Antidepressants on HALO^® Elevate

Omeprazole Analysis Using HALO^® Elevate C18

The organo-silane-modified surface makes these columns very stable at high pH values.

When analysing amitriptyline at a pH value of 10, it was found that the retention only shifted by 1 % after 500 injections (or 20,000 column volumes).

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