pp-Pure Vial - Polypropylene Vial for Sample Volumes from 100

pp-Pure Vial - Polypropylene Vial for Sample Volumes from 100 - 700 μl

Until a few years ago, the emphasis of pharmaceutical research was on small molecules, while today the focus is more on big molecules, such as peptides and proteins. Big molecules are easily adsorbed on the glass surface, so that glass vials need to be silanized; for aqueous samples polymer vials may be used.

We found and use a unique pure polypropylene containing no softeners, which can be used in injection moulding. In the process, the polypropylene is pressed into the form and shrinks in the cooling process leaving some vacant spots. If we used polypropylene with a softener, we could simply inject some more polypropylene into the mould to "fill" these vacant spots. With as pure a material as we are using, this is not possible, so small vacuum bubbles remain. This however is only a blemish and proof of the purity of the material.

The inner form of the vial, designed for optimized micro sampling, is ideal for taking smallest
sample volumes and allows to work in a range from 100 - 700 µl sample volume.

Because of the high inner base, the pp-Pure vial is suitable for working with very small sample volumes and depending on needle geometry the actual non-injectable volume is extremely small. We recommend to adjust the needle height to ≥ 3.5 mm above base of the vial.

G002-SC-PP/i17µ

Snap Crimp Vial for use with Aluminium Crimp Caps and Snap Caps
100 - 700 µl
pp-Pure Polypropylene
Size: 12 x 32 mm

G004-HP-PP/i17µ

Agilent Technologies compatible Screw Vial
100 - 700 µl
pp-Pure Polypropylene
Size: 12 x 32 mm

Test Conditions:
A pp-Pure Vial and a commercial polypropylene vial were filled with a mixture of 1 : 1 Acetonitrile/Water. In addition, the pp-Pure Vial was immersed into a container containing the same solvent. After an incubation period of approx. 24h at room temperature, the solvents in the three containers were analysed for UV-active impurities from the containers‘ material by means of RP-HPLC

HPLC-Method:
The extracts were separated by RP-HPLC and an Acetonitrile gradient. Detection was carried out in a low UV-range. This screening method allows the recording of a wide spectrum of potential extractables. A mixture of the main impurities which we looked for of often used plastic additives with a concentration of 2.5 mg/L each was used as comparison. The sensitivity of the method lies at approx. 0.5 mg/L (0.5 ppm).

PP-Pure Vial
In comparison with the blank there were no additional
signals detected.

Commercial Polypropylene Vial
In comparison to the blank there was a bigger signal in the retention area of 23 minutes.